Laboratory of Space Medicine and Space Pharmacology

Space Biology and Life Sciences, Professor Dr. med. Daniela Gabriele Grimm



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Clinostat

Clinostat (Laboratory Ruth Hemmersbach, DLR, Cologne)



Random Positioning Machine

Random Positioning Machine (Laboratory Marcel Egli, ETH Zurich)



Rotating Wall Vessel

Rotating Wall Vessel

Publications of Professor Daniela Gabriele Grimm, MD, Department of Pharmacology, University of Aarhus

 

List of Publications 2000-2016

2017

Pietsch J, Gass S, Nebuloni S, Echegoyen D, Riwaldt S, Baake C, Bauer J, Corydon TJ, Egli M, Infanger M, Grimm D. Three-dimensional growth of human endothelial cells in an automated cell culture experiment container during the SpaceX CRS-8 ISS space mission - The SPHEROIDS project. Biomaterials 2016, in press.

2016

Frippiat J-P, Crucian BE, de Quervain DJ-F, Grimm D, Montano N, Praun S, Roozendaal B, Schelling G, Thiel M, Ullrich O, Choukèr A. Towards human exploration of space: The THESEUS review series on immunology research priorities. npj Microgravity 2016; 2, Article number: 16040. doi:10.1038/npjmgrav.2016.40

Corydon TJ, Mann V, Slumstrup L, Kopp S, Sahana J, Askou AL, Magnusson NE, Echegoyen D, Bek T, Sundaresan A, Riwaldt S, Bauer J, Infanger M, Grimm D. Reduced Expression of Cytoskeletal and Extracellular Matrix Genes in Human Adult Retinal Pigment Epithelium Cells Exposed to Simulated Microgravity. Cell Physiol Biochem. 2016;40(1-2):1-17.

Frandsen S, Kopp S, Wehland M, Pietsch J, Infanger M, Grimm D. Latest Results for Anti-Angiogenic Drugs in Cancer Treatment. Curr Pharm Des. 2016 Jul 15. [Epub ahead of print]

Laursen R, Wehland M, Kopp S, Pietsch J, Infanger M, Grosse J, Grimm D. Effects and Role of Multikinase Inhibitors in Thyroid Cancer. Curr Pharm Des. 2016 Jun 13. [Epub ahead of print]

Bauer J, Bussen M, Wise P, Wehland M, Schneider S, Grimm D. Searching the literature for proteins facilitates the identification of biological processes, if advanced methods of analysis are linked: a case study on microgravity-caused changes in cells. Expert Rev Proteomics. 2016 Jul;13(7):697-705.

Kopp S, Slumstrup L, Corydon TJ, Sahana J, Aleshcheva G, Islam T, Magnusson NE, Wehland M, Bauer J, Infanger M, Grimm D. Identifications of novel mechanisms in breast cancer cells involving duct-like multicellular spheroid formation after exposure to the Random Positioning Machine. Sci Rep. 2016 May 27;6:26887.

Riwaldt S, Bauer J, Wehland M, Slumstrup L, Kopp S, Warnke E, Dittrich A, Magnusson NE, Pietsch J, Corydon TJ, Infanger M, Grimm D. Pathways Regulating Spheroid Formation of Human Follicular Thyroid Cancer Cells under Simulated Microgravity Conditions: A Genetic Approach. Int J Mol Sci. 2016 Apr 8;17(4):528.

Grimm D, Grosse J, Wehland M, Mann V, Reseland JE, Sundaresan A, Corydon J. The impact of microgravity on bone in humans. Bone. 2016 Jun;87:44-56.

Aleshcheva G, Bauer J, Hemmersbach R, Slumstrup L, Wehland M, Infanger M, Grimm D. Scaffold-free Tissue Formation under Real and Simulated Microgravity Conditions. Basic Clin Pharmacol Toxicol. 2016 Oct;119 Suppl 3:26-33.

Corydon JT, Kopp, S, Wehland M, Braun M, Schütte A, Mayer T, Hülsing T, Oltmann H, Schmitz B, Hemmersbach R, Grimm D. Alterations of the cytoskeleton in human cells in space proved by life-cell imaging. Sci Rep. 2016 Jan 28;6:20043.

Andersen MB, Simonsen U, Wehland M, Pietsch J, Grimm D. LCZ696 (Valsartan/Sacubitril) - A possible new treatment for hypertension and heart failure. Basic Clin Pharmacol Toxicol. 2016 Jan;118(1):14-22.

Warnke E, Kopp S, Wehland M, Hemmersbach R, Bauer J, Pietsch J, Infanger M, Grimm D. Thyroid cells exposed to simulated microgravity conditions? Comparison of the fast rotating clinostat and the Random Positioning Machine. Microgravity Sci. Technol. 2016;28:247-260.

Aleshcheva G, Bauer J, Hemmersbach R, Egli M, Wehland M, Grimm D. Tissue engineering of cartilage on ground-based facilities. Microgravity Sci. Technol. 2016;28:237-245.

Bauer J, Wehland M, Pietsch J, Sickmann A, Weber G, Grimm D. Annotated gene and proteome data support recognition of interconnections between the results of different experiments in space research. Microgravity Sci. Technol. 2016;28:357-365.

Wehland M, Warnke E, Frett T, Hemmersbach R, Hauslage J, Ma X, Alehcheva G, Pietsch J, Bauer J, Grimm D. The impact of microgravity and vibration on gene and protein expression of thyroid cells. Microgravity Sci. Technol. 2016;28:261-274.


2015

Riwaldt S, Bauer J, Pietsch J, Braun M, Segerer J, Schwarzwälder A, Corydon TJ, Infanger M, Grimm D. The Importance of Caveolin-1 as Key-Regulator of Three-Dimensional Growth in Thyroid Cancer Cells Cultured under Real and Simulated Microgravity Conditions. Int J Mol Sci. 2015 Nov 30;16(12):28296-310

Kopp S, Warnke E, Wehland M, Aleshcheva G, Magnusson NE, Hemmersbach R, Juhl Corydon T, Bauer J, Infanger M, Grimm D. Mechanisms of three-dimensional growth of thyroid cells during long-term simulated microgravity. Sci Rep. 2015 Nov 18;5:16691

Svejgaard B, Wehland M, Ma X, Kopp S, Sahana J, Warnke E, Aleshcheva G, Hemmersbach R, Hauslage J, Grosse J, Bauer J, Corydon TJ, Islam T, Infanger M, Grimm D. Common effects on cancer cells exerted by a Random Positioning Machine and a 2D Clinostat. PLoS One. 2015;10:e0135157.

Riwaldt S, Pietsch J, Sickmann A, Bauer J, Braun M, Segerer J, Schwarzwälder A, Aleshcheva G, Corydon TJ, Infanger M, Grimm D. Identification of proteins involved in inhibition of spheroid formation under microgravity. Proteomics. 2015;15:2945-52

Wehland M, Aleshcheva G, Schulz H, Saar H, Hübner N, Hemmersbach R, Braun M, Ma X, Frett T, Warnke E, Riwaldt S, Pietsch J, Corydon TJ, Infanger M, Grimm D: Differential gene expression of human chondrocytes cultured under short-term altered gravity conditions during parabolic flight maneuvers. Cell Commun Signal. 2015;13:18

Fisker FY, Grimm D, Wehland M: Third-generation beta-adrenoceptor antagonists in the treatment of hypertension and heart failure. Basic Clin Pharmacol Toxicol. 2015;117:5-14

Aleshcheva G, Wehland M, Sahana J, Bauer J, Corydon TJ, Hemmersbach R, Frett T, Egli M, Infanger M, Grosse J, Grimm D: Moderate alterations of the cytoskeleton in human chondrocytes after short-term microgravity produced by parabolic flight maneuvers could be prevented by up-regulation of BMP-2 and SOX-9. FASEB J. 2015;29:2303-14.

Wuest SL, Richard S, Kopp S, Grimm D, Egli M: Simulated Microgravity: Critical Review on the Use of Random Positioning Machines for Mammalian Cell Culture. Biomed Res Int. 2015;2015:971474.


2014

Kristensen TB, Knutsson ML, Wehland M, Laursen BE, Grimm D, Warnke E, Magnusson NE: Anti-Vascular Endothelial Growth Factor Therapy in Breast Cancer. Int J Mol Sci. 2014;15:23024-23041.

Nielsen OH, Grimm D, Wehland M, Bauer J, Magnusson NE: Anti-Angiogenic Drugs in the Treatment of Metastatic Renal Cell Carcinoma:Advances in Clinical Application. Curr Vasc Pharmacol. 2015;13:381-91.

Ulbrich C, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Magnusson N, Infanger M, Grosse J, Eilles C, Sundaresan A, Grimm D: The impact of simulated and real microgravity on bone cells and mesenchymal stem cells. Biomed Res Int. 2014;2014:928507. doi: 10.1155/2014/928507.

Grimm D, Pietsch J, Wehland M, Richter P, Strauch SM, Lebert M, Magnusson NE, Wise P, Bauer J: The impact of microgravity-based proteomics research. Expert Rev Proteomics. 2014;11:465-476.

Grimm D, Wehland M, Pietsch J, Aleshcheva G, Wise P, van Loon J, Ulbrich C, Magnusson NE, Infanger M, Bauer J: Growing Tissues in Real and Simulated Microgravity: New Methods for Tissue Engineering. Tissue Eng Part B Rev. 2014;20:555-66.

Warnke E, Pietsch J, Wehland M, Bauer J, Infanger M, Görög M, Hemmersbach R, Braun M, Ma X, Sahana J, Grimm D: Spheroid formation of human thyroid cancer cells under simulated microgravity: a possible role of CTGF and CAV1. Cell Commun Signal. 2014;12:32.

Ma X, Pietsch J, Wehland M, Schulz H, Saar K, Hübner N, Bauer J, Braun M, Schwarzwälder A, Segerer J, Birlem M, Horn A, Hemmersbach R, Wasser K, Grosse J, Infanger M, Grimm D: Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space. FASEB J. 2014;28:813-835.

Ma X, Sickmann A, Pietsch J, Wildgruber R, Weber G, Infanger M, Bauer J, Grimm D: Proteomic differences between microvascular endothelial cells and the EA.hy926 cell line forming three-dimensional structures. Proteomics. 2014;14:689-698.

Grosse J, Warnke E, Wehland M, Pietsch J, Pohl F, Wise P, Magnusson NE, Eilles C, Grimm: Mechanisms of apoptosis in irradiated and sunitinib-treated follicular thyroid cancer cells. Apoptosis. 2014;19:480-490.

Wildgruber R, Weber G, Wise P, Grimm D, Bauer J: Free flow electrophoresis in proteome sample preparation. Proteomics. 2014;14:629-636.


2013

Aleshcheva G, Sahana J, Ma X, Hauslage J, Hemmersbach R, Egli M, Infanger M, Bauer J, Grimm D: Changes in morphology, gene expression and protein content in chondrocytes cultured on a random positioning machine. PLoS One. 2013;8:e79057.

Grimm D, Bauer J, Hemmersbach R, Ulbrich C, Pietsch J, Wehland M, Infanger M: Biotechnological use of weightlessness for medical research -analysis of human cells after weightlessness. Flug u Reisemed. 2013;20:173-178.

Grosse J, Warnke E, Pohl F, Magnusson NE, Wehland M, Infanger M, Eilles C, Grimm D. Impact of sunitinib on human thyroid cancer cells. Cell Physiol Biochem. 2013;32:154-170.

Pietsch J, Ma X, Wehland M, Aleshcheva G, Schwarzwälder A, Segerer J, Birlem M, Horn A, Bauer J, Infanger M, Grimm D. Spheroid formation of human thyroid cancer cells in an automated culturing system during the Shenzhou-8 Space mission. Biomaterials. 2013;34:7694-7670.

Ma X, Wehland M, Aleshcheva G, Hauslage J, Wasser K, Hemmersbach R, Infanger M, Bauer J, Grimm D. Interleukin-6 Expression under Gravitational Stress Due to Vibration and Hypergravity in Follicular Thyroid Cancer Cells. PLoS One. 2013;8:e68140.

Ma X, Wehland M, Schulz H, Saar K, Hübner N, Infanger M, Bauer J, Grimm D. Genomic approach to identify factors that drive the formation of three-dimensional structures by EA.hy926 endothelial cells. PLoS One. 2013;8:e64402.

Wehland M, Bauer J, Magnusson NE, Infanger M, Grimm D. Biomarkers for anti-angiogenic therapy in cancer. Int J Mol Sci. 2013;14:9338-9364.

Wehland M, Ma X, Braun M, Hauslage J, Hemmersbach R, Bauer J, Grosse J, Infanger M, Grimm D. The impact of altered gravity and vibration on endothelial cells during a parabolic flight. Cell Physiol Biochem. 2013;31:432-451.

Pietsch J, Riwaldt S, Bauer J, Sickmann A, Weber G, Grosse J, Infanger M, Eilles C, Grimm D. Interaction of proteins identified in human thyroid cells. Int J Mol Sci. 2013;14:1164-1178.


2012

Grosse J, Wehland M, Pietsch J, Schulz H, Saar K, Hübner N, Eilles C, Bauer J, Abou-El-Ardat K, Baatout S, Ma X, Infanger M, Hemmersbach R, Grimm D. Gravity-sensitive signaling drives 3-dimensional formation of multicellular thyroid cancer spheroids. FASEB J. 2012;26:5124-5140.

Magnusson NE, Dyrskjøt L, Grimm D, Wehland M, Pietsch J, Rungby J. Gene Networks Modified by Sulphonylureas in Beta Cells: A Pathway-based Analysis of Insulin Secretion and Cell Death. Basic Clin Pharmacol Toxicol. 2012, 111:254-61.

Pietsch J, Sickmann A, Weber G, Bauer J, Egli M, Wildgruber R, Infanger M, Grimm D. Metabolic enzyme diversity in different human thyroid cell lines and their sensitivity to gravitational forces. Proteomics 2012, 12:2539-46.

Wehland M, Bauer J, Infanger M, Grimm D. Target-based Anti-angiogenic Therapy in Breast Cancer. Curr Pharm Des. 2012,18:4244-4257.

Ma X, Wildgruber R, Bauer J, Weber G, Infanger M, Grosse J, Grimm D. The use of sigmoid pH gradients in free-flow isoelectric focusing of human endothelial cell proteins. Electrophoresis 2012,33:1349-1355.

Grosse J, Meier K, Bauer TJ, Eilles C, Grimm D. Cell separation by countercurrent centrifugal elutriation: recent developments. Prep Biochem Biotechnol. 2012;42:217-2133.

Grosse J, Wehland M, Pietsch J, Ma X, Ulbrich C, Schulz H, Saar K, Hübner N, Hauslage J, Hemmersbach R, Braun M, van Loon J, Vagt N, Infanger M, Eilles C, Egli M, Richter P, Baltz T, Einspanier R, Sharbati S, Grimm D: Short-term weightlessness produced by parabolic flight maneuvers altered gene expression patterns in human endothelial cells. FASEB J.2012;26:639-655.

Wehland M, Grosse J, Simonsen U, Infanger M, Bauer J, Grimm D. The Effects of Newer Beta-Adrenoceptor Antagonists on Vascular Function in Cardiovascular Disease. Curr Vasc Pharmacol. 2012;10:378-390.


2011

Grimm D, Bauer J, Pietsch J, Infanger M, Eucker J, Eilles C, Schoenberger J. Diagnostic and therapeutic use of membrane proteins in cancer cells. Curr Med Chem 2011;18:176-190.

Grimm D, Wise P, Lebert M, Richter P, Baatout S. How and why does the proteome respond to microgravity? Expert Rev Proteomics 2011;8:13-27.

Grimm, Wehland M, Pietsch J, Infanger M, Bauer J. Drugs interfering with apoptosis in breast cancer. Curr Pharm Des. 2011;17:272-283.

Pietsch J, Sickmann M, Weber G, Bauer J, Egli M, Wildgruber R, Infanger M, Grimm D. A proteomic approach to analysing spheroid formation of two human thyroid cell lines cultured on a random positioning machine. Proteomics 2011;11:2095-2104.

Pietsch J, Sickmann A, Bauer J, Weber G, Nissum M, Westphal K, Egli M, Grosse J, Schönberger J, Eilles C, Infanger M, Grimm D. Proteome analysis of thyroid cancer cells after long-term exposure to simulated microgravity. Microgravity, Science and Technology 2011;23:381-390.

Pietsch J, Bauer J, Egli M, Infanger M, Wise P, Ulbrich C, Grimm D. The effects of weightlessness on the human organism and mammalian cells. Curr Mol Med. 2011;11:350-364.

Wohllebe S, Ulbrich C, Grimm D, Pietsch J, Erzinger G, Richter R, Lebert M, Richter PR, Häder DP. Photodynamic Treatment of Chaoborus crystallinus Larvae with Chlorophyllin Induces Necrosis and Apoptosis. Photochem Photobiol. 2011;87:1113-22.

Ulbrich C, Pietsch J, Grosse J, Wehland M, Schulz H, Saar K, H?bner N, Hauslage J, Hemmersbach R, Braun M, van Loon J, Vagt N, Egli M, Richter P, Einspanier R, Sharbati S, Baltz T, Infanger M, Grimm D. Differential gene regulation under altered gravity conditions in follicular thyroid cancer cells: Relationship between extracellular matrix and the cytoskeleton. Cell Physiol Biochem. 2011;28:185-198.


2010

Ulbrich C, Leder A, Pietsch J, Flick B, Wehland M, Grimm D: The impact of vascular endothelial growth factor and basic fibroblast growth factor on cardiac fibroblasts grown under altered gravity conditions. Cell Physiol Biochem 2010;26:1011-1022.

Grimm D , Bauer J, Ulbrich C, Westphal K, Wehland M, Infanger M, Aleshcheva G, Pietsch J, Ghardi M, Beck M, El-Saghire H, de Saint-Georges L, Baatout S. Different responsiveness of endothelial cells to vascular endothelial growth factor and basic fibroblast growth factor added to culture media under gravity and simulated microgravity. Tissue Eng Part A. 2010;16:1559-1573.

Ulbrich C, Westphal K, Pietsch J, Winkler HDF, Leder A, Bauer J, Kossmehl P, Grosse J, Schoenberger J, Infanger M, Egli M, Grimm D . Characterization of human chondrocytes exposed to simulated microgravity. Cell Physiol Biochem 2010;25:551-560.

Pohl F, Grosse J, Grimm D , Brockhoff G, Schmidt-Bruecken E, Westphal K, Moosbauer J, Koelbl O, Infanger M, Eilles C, Schoenberger J. Changes of apoptosis, p53 and bcl-2 by irradiation in poorly differentiated thyroid carcinoma cell lines : a prognostic marker for prospect of therapeutic success? Thyroid 2010;20:159-166.

Pietsch J, Kussian R, Sickmann A, Bauer J, Weber G, Nissum M, Westphal K, Egli M, Grosse J, Schönberger J, Wildgruber R, Infanger M, Grimm D . Application of free-flow isoelectric focusing to identify protein candidates changing under microgravity conditions. Proteomics 2010;10:904-913.


2009

Grimm D , Bauer J, Schönberger J. Blockade of neoangiogenesis, a new and promising technique to control the growth of malignant tumors and its metastases. Current Vascular Pharmacology 2009:7:347-357.

Grimm D , Infanger M, Westphal K, Ulbrich C, Pietsch J, Kossmehl P, Vadrucci S, Baatout S, Flick B, Paul M, Bauer J. A delayed type of three-dimensional growth of human endothelial cells under simulated weightlessness. Tissue Eng Part A. 2009;15:2267-2275.

Grosse J, Grimm D *, Westphal K, Ulbrich C, Moosbauer J, Pohl F, Koelbl O, Infanger M, Eilles C, Schoenberger, J. Radiolabeled annexin V for imaging apoptosis in radiated human follicular thyroid carcinomas ? is an individualized protocol necessary). Nucl Med Biol. 2009;36:89-98. *equal contribution

Infanger M, Grimm D . Meniscus and Discus lesions of Triangular Fibrocartilage Complex (TFCC): Treatment by laser-assisted wrist arthroscopy. J Plast Reconstr Aesthet Surg. 2009;62:466-471.


2008

Schoenberger J, Bauer J, Moosbauer J, Eilles C, Grimm D . Innovative strategies in vivo apoptosis imaging. Curr Med Chem. 2008;15:187-194.

Ulbrich C, Westphal K, Baatout S, Wehland M, Bauer J, Flick B, Infanger M, Kreutz R, Vadrucci S, Egli M, Cogoli A, Derradji H, Pietsch J, Paul M, Grimm D . Effects of basic fibroblast growth factor on endothelial cells under conditions of simulated microgravity. J Cell Biochem. 2008;104:1324-1341.

Infanger M, Grosse J, Westphal K, Leder A, Ulbrich C, Paul M, Grimm D . Vascular Endothelial Growth Factor induces extracellular matrix proteins and osteopontin in the umbilical artery. Ann Vasc Surg. 2008;22:273-284.

Schulz A, Schlesener M, Weiss J, Hänsch J, Wendt N, Kossmehl P, Grimm D , Vetter R, Kreutz R. The protective effect of female gender on the development of albuminuria in a polygenetic rat model is further enhanced by replacement of a major autosomal QTL. Clin Sci (Lond). 2008;114:305-311.


2007

Infanger M, Faramarzi S, Grosse J, Kurth E, Ulbrich C, Bauer J, Wehland M, Kreutz R, Kossmehl P, Paul M, Grimm D . Expression of Vascular endothelial growth factor and receptor tyrosine kinases in cardiac ischemia-reperfusion injury. Cardiovascular Pathology 2007;16:291-299

Infanger M, Ulbrich C, Baatout S, Wehland M, Kreutz R, Bauer J, Grosse J, Vadrucci S, Cogoli A, Derradji H, Neefs M, Küster S, Spain S, Paul M, Grimm D . Modeled gravitational unloading induced downregulation of endothelin-1 in human endothelial cells. J Cell Biochem. 2007;101:1439-1455.

Wendt N, Schulz A, Siegel AK, Weiss J, Wehland M, Sietmann A, Kossmehl P, Grimm D , Stoll M, Kreutz R. Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats. J Hypertens. 2007;25:95-102.

Schulz A, Weiss J, Schlesener M, Wehland M, Wendt N, Kossmehl P, Anika Sietmann A, Grimm D , Stoll M, Randel Nyengaard J, Kreutz R. The development of overt proteinuria in the MWF rat is suppressed by replacement of chromosome 6 in a consomic rat strain. J Am Soc Nephro, 2007;18:113-121


2006

Infanger M, Kossmehl P, Shakibaei M, Bauer J, Kossmehl-Zorn S, Cogoli A, Curcio F, Oksche A, Wehland M, Kreutz R, Paul M, Grimm D . Simulated weightlessness changes the cytoskeleton and extracellular matrix proteins in papillary thyroid carcinoma cells. Cell and Tissue Res 2006;324:267-277.

Infanger M, Kossmehl P, Shakibaei M, Baatout S, Bauer J, Grosse J, Witzing A, Cogoli A, Faramarzi S, Derradji H, Neefs M, Paul M, Grimm D . Induction of three-dimensional assembly and increase in apoptosis of human endothelial cells by simulated microgravity. Impact of vascular endothelial growth factor. Apoptosis 2006;11:749-764.

Kossmehl P, Kurth E, Faramarzi S, Habighorst B, Shakibaei M, Wehland M, Kreutz R, Infanger M, Danser AHJ, Grosse J, Paul M, Grimm D . Mechanisms of apoptosis after ischemia and reperfusion: Role of the Renin-Angiotensin System. Apoptosis 2006;11:347-358.

Grimm D , Bauer J, Infanger M, Cogoli A. The use of the random positioning machine for the study of gravitational effects on signal transduction in mammalian cells.Signal Transduction. 2006;6:388-396.

Infanger M, Baum E, Grimm D , Ertel W. Palmar Reduction And Internal Fixation For Displaced Intraarticular fractures of the radius with locking compression plate: Operative strategy leads to functional treatment J. Orthopaedics. 2006;3:e12

Infanger M, Kossmehl P, Grimm D . Successful microsurgical primary replantation of an amputated cheek. Acta Otolaryngol 2006;126:432-434.

Rothermund L, Nierhaus M, Fialkowski O, Freese F, Ibscher R, Mieschel S, Kossmehl P, Grimm D , Wehland M, Kreutz R. Genetic low nephron number hypertension is associated with dysregulation of the hepatic and renal insulin-like growth factor system during nephrogenesis. J Hypertens 2006;24:1857-1864.


2005

Infanger M, Kossmehl P, Grimm D . Surgical and medical management of rare echinococcosis of the extremities: pre- and post-operative long-term chemotherapy. Scand J Infect Dis 2005;37:954-957.

Kossmehl P, Schönberger J, Shakibaei M, Faramarzi S, Kurth E, Habighorst B, von Bauer R, Wehland M, Kreutz R, Infanger M, Schulze-Tanzil G, Paul M, Grimm D. Increase of fibronectin and osteopontin in porcine hearts following ischemia and reperfusion. J Mol Med 2005;83:626-637.

Infanger M, Shakibaei M, Kossmehl P, Hollenberg SM, Grosse J, Faramarzi S, Schulze-Tanzil G, Paul M, Grimm D. Intraluminal application of VEGF enhances healing of microvascular anastomosis in a rat model. J Vasc Res 2005;42:202-213.

Obermaier C, Jankowski V, Schmutzler C, Bauer J, Wildgruber R, Infanger M, Köhrle J, Krause E, Weber G, Grimm D . Improved Sample Preparation for Free Flow-Isoelectric Focusing: Identification of Human Thyroid Cancer Cell Proteins. Electrophoresis 2005;26:2109-2116.


2004

Schoenberger J+, Grimm D +, Kossmehl P, Infanger M, Kurth E, Eilles C. Effects of PTK787/ZK222584 a tyrosine kinase inhibitor on the growth of a poorly differentiated thyroid carcinoma. An animal study. Endocrinology 2004;145:1031-1038. (+JS and DG contributed equally)

Infanger M Kossmehl P, Shakibaei M, Schulze-Tanzil G, Cogoli A, Faramarzi S, Bauer J, Curcio F, Paul M, Grimm D . Long-term conditions of mimicked weightlessness influences the cytoskeleton in thyroid carcinoma cells. J Gravit Physiol 2004;11:P169-172.

Infanger M, Kossmehl P, Shakibaei M, Cogoli A, Witzing A, Faramarzi S, Wittfoht W, Paul M, Grimm D . Vascular endothelial growth factor inhibits programmed cell death of endothelial cells induced by clinorotation. J Gravit Physiol 2004;11:P199-200.

Infanger M, Schmidt O, Kossmehl P, Grad S, Ertel W, Grimm D . Vascular endothelial growth factor serum level is strongly enhanced after burn injury and correlated with local and general tissue edema. Burns 2004;30:305-311.


2003

Kossmehl P, Shakibaei M, Cogoli A, Infanger M, Curcio F, Schönberger J, Eilles C, Bauer J, Pickenhahn H, Schulze-Tanzil G, Paul M, Grimm D. Weightlessness-induced apoptosis in normal thyroid cells and papillary thyroid carcinoma cells via extrinsic and intrinsic pathways. Endocrinology 2003;9:4172-4179.

Nogueira AC, Ast I, Patone G, Perschel FH, Grimm D , Paul M. Functional effects of acute coronary occlusion and catecholaminergic stimuli on the isolated normothermic hemoperfused porcine heart. Clinical and Experimental Hypertension 2003;25:235-255.


2002

Grimm D , Kossmehl P, Jabusch HC, Krämer BK, Fredersorf S, Kromer EP. Experimental diabetes and left ventricular hypertrophy. Effects of beta-receptor blockade. Cardiovascular Pathology 2002;11:229-237.

Kossmehl P, Cogoli A, Shakibaei M, Pickenhahn H, Paul M and Grimm D . Simulated microgravity induces programmed cell death in human thyroid carcinoma cells. J Gravit Physiol 2002;9:P295-296.

Grimm D , Kossmehl P, Shakibaei M, Schulze-Tanzil G, Pickenhahn H, Bauer J, Paul M and Cogoli A. Effects of simulated microgravity on thyroid carcinoma cells. J Gravit Physiol 2002;9:P253-256

Grimm D , Bauer J, Kossmehl P, Shakibaei M, Schoenberger J, Pickenhahn H, Schulze-Tanzil G, Vetter R, Eilles C, Paul M, Cogoli A. Simulated microgravity alters differentiation and increases apoptosis in human follicular thyroid thyroid carcinoma cells. FASEB J 2002;16:604-606.

Rothermund L, Kreutz R, Kossmehl P, Fredersdorf S, Shakibaei M, Schulze-Tanzil G, Paul M, Grimm D . Early onset of chondroitin sulfate and osteopontin expression in Angiotensin II-dependent left ventricular hypertrophy. Am J of Hypertension 2002;15:644-652.

Kammerl MC, Grimm D , Kromer EP, Jabusch HC, Reif R, Morhard S, Endemann D, M. Fischereder M, iegger GAJ, Krämer BK. Effects of aortic stenosis on renal renin, angiotensin receptor, endothelin and NOS gene expression in rats. Am J Nephrol 2002;22:84-89.

Riecke K, Grimm D , Shakibaei M, Kossmehl P, Schulze-Tanzil G, Paul M, Stahlmann R. Low doses of 2,3,7,8-tetrachlorodibenzo-p-dioxin increase transforming growth factor β and cause myocardial fibrosis in marmosets (Callithrix jacchus). Arch Toxicol 2002;76:360-366.

Schönberger J, Rüschoff J, Grimm D , Marienhagen J, Rümmele P, Meyringer R, Kossmehl P, Hofstädter F, Eilles C. Glucose transporter 1 (glut1) gene expression is related to thyroid neoplasms with an unfavorable prognosis. An immunohistochemical study. Thyroid 2002;12:747-754.


2001

Grimm D , Huber M, Jabusch HC, Shakibaei M, Fredersdorf S, Paul M, Riegger GAJ, Kromer EP. Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload. Effects of beta-receptor blockade. J Mol Cell Cardiol 2001;33:487-501.


2000

Schönberger J, Bauer J, Weber G, Spruß T, Paul M, Eilles C, Grimm D . Establishment and characterization of a human thyroid carcinoma cell line ML-1. J Mol Med 2000:78:102-110.

Weber G, Grimm D , Bauer J. Application of binary buffer systems to free flow cell electrophoresis. Electrophoresis 2000;21:325-328.

Kammerl M, Grimm D , Nabel C, Schweda F, Bach M, Fredersdorf S, Piehler H, Holmer SR, Riegger GAJ, Kromer EP, Krämer BK. Effects of growth hormone on renal renin gene expression in normal rats and rats with myocardial infarction. Nephrology Dialysis Transplantation 2000;15:786-790.

Böcker W, Hupf H, Grimm D , Kurzidim K, Schunkert H. Effects of indipamide in rats with pressure overload left ventricular hypertrophy. J of Cardiovasc Pharmacol 2000;36:481-486.


Books and monographs

Bauer J, Grimm D .
Effect of gravitational stress on major cell functions: Growth, differentiation, apoptosis adhesion/migration' in Cell Mechanochemistry. Biological Systems and Factors Inducing Mechanical Stress, Such as Light Pressure and Gravity,
Transworld Research Network 2009 in press

Riecke K, Grimm D , Shakibaei M, Kossmehl P, Schulze-Tanzil G, Paul M, Stahlmann R.
2,3,7,8-Tetrachloro-dibenzo-p-dioxin induces myocardial fibrosis in marmosets (Callithrix Jacchus) Organohalogen Compounds 2002;55:351-354.

Grimm D , Schönfelder G, Paul M.
Apoptosis in cardiac myocytes. Effects of Angiotensin II in Apoptosis in Cardiac Biology edited by Schunkert H, Riegger GAJ.
Kluwer Academic Publishers, Boston-Dordrecht-London 1999; 317-327.

Grimm D , Hofstädter F, Höhne HM, Bauer J, Spruss T, Steinbach P.
Etablierung und Charakterisierung einer humanen papillären Schilddrüsenkarzinomzelllinie mit onkozytärer Differenzierung.
Verh Dtsch Ges Path 1991;75:347.

Grimm D , Hofstädter F, Bauer J, Steinbach P. Multizelluläre Schilddrüsentumorsphäroide in Kokultur mit humanen venösen Endothelzellen.
Verh Dtsch Ges Path 1991;75:484.

 

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